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Control of the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercaptoof the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercapto-1

Yongli WANG, Shuyuan MA, Xiaodong Lü, Chuang XIE

《化学科学与工程前沿（英文）》 2012年第6卷第4期页码 423-431 doi: 10.1007/s11705-012-1211-7

摘要： 5-(Difluoromethoxy)-2-mercapto-1 -benzimidazole (DMB) was precipitated by adding acetic acid to the DMB sodium salt solution. The spherical agglomeration of DMB during the reactive crystallization in a batch crystallizer was monitored by real-time Particle Video Microscope (PVM). We found that the low feeding rate of acetic acid, high crystallization temperature, low agitation rate or adding seed crystal can facilitate the formation of spherical agglomerates. By using a simple model, the mean crystal agglomerate size of DMB thus predicted is generally in agreement with the experimental data. In addition, the crystallization process of DMB was optimized by a new control strategy of supersaturation to avoid disadvantages brought by agglomeration.

关键词： 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (DMB) reactive crystallization agglomeration feeding rate crystallization temperature agitation rate

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

《化学科学与工程前沿（英文）》 2009年第3卷第3期页码 305-309 doi: 10.1007/s11705-009-0021-z

摘要： A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

关键词： benzimidazole coxsackie virus B₃ antiviral properties

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

《农业科学与工程前沿（英文）》 2016年第3卷第1期页码 11-24 doi: 10.15302/J-FASE-2016092

摘要： The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and become endemic since 1998 and 2004, respectively. Currently, they are prevalent in poultry throughout China. This endemicity makes them actively involved in the emergence of the novel lineages of other subtypes of influenza viruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2 and the 2013 novel H7N7, H7N9 and H10N8 subtypes, thereby threatening both the poultry industry and public health. Here, we will review briefly the prevalence and evolution, pathogenicity, transmission, and disease control of these two subtypes and also discuss the possibility of emergence of potentially virulent and highly transmissible AIVs to humans.

关键词： avian influenza virus H9N2 H5N1 novel viruses public health

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1,5-戊二胺的细菌合成及应用 Review

马伟超, 陈可泉, 李艳, 郝宁, 王昕, 欧阳平凯

《工程（英文）》 2017年第3卷第3期页码 308-317 doi: 10.1016/J.ENG.2017.03.012

摘要：

1,5-戊二胺是一种广泛分布于原核和真核生物中的具有多种生物活性的天然多胺，正日益成为一种重要的工业化学品，并在多个领域展现出广泛的应用前景，特别是作为单体用于合成生物基聚酰胺。基于1,5-戊二胺的聚酰胺5X 具有优异的性能和环境友好特性，因而有广泛的应用前景。本文总结了近期关于1,5-戊二胺在细菌中的生物合成、代谢及生理学功能，着重介绍了1,5-戊二胺在大肠杆菌的代谢调控机制。文中还综述了微生物发酵法和全细胞催化法生产1,5-戊二胺的进展及1,5-戊二胺的分离纯化方法。此外，对1,5-戊二胺在生物基聚酰胺合成中的应用进行了总结，并对利用可再生资源生产1,5-戊二胺进行了展望和对以后的研究提出了建议。

关键词： 1 5-戊二胺代谢细菌生产生物基聚酰胺 PA 5X

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Improvement in the synthesis of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid 2-benzothiazolyl

GAO Shihao, SUN Chenghui, ZHAO Xinqi, GAO Changquan

《化学科学与工程前沿（英文）》 2008年第2卷第1期页码 80-84 doi: 10.1007/s11705-008-0017-0

摘要： 2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid 2-benzothiazolyl thioester(III), an important intermediate of the fourth generation cephalosporins, was efficiently synthesized by reacting 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid (I) with 2,2′-dibenzothiazole disulfide (II) in the presence of triphenylphosphine. Effects of reaction time, temperature, solvents, catalysts and feeding molar ratio on the yield and quality of products were investigated, and an improved procedure suitable for industrial production was established. Using 1,2-dichloroethane as solvent, triphenylphosphine as reducer, and triethylamine as catalyst, (I) : (II) : (triphenylphosphine) = 1.0 : 1.0 : 1.0, the product was obtained at room temperature in 98.1% yield. The purity of the product without further purification is 98.7% determined by HPLC method. This procedure could be a suitable alternative to the traditional processes because of its easy handling, high yield and low cost.

关键词： 5-Amino-1 2 4-thiadiazol-3-yl 1 2-dichloroethane important intermediate 2-benzothiazolyl thioester temperature

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一种新型灰狼优化算法及其在5G频率选择表面设计中的应用 Research Article

何志豪1,2,3,晋刚1,2,3,王英俊1,2,3

《信息与电子工程前沿（英文）》 2022年第23卷第9期页码 1338-1353 doi: 10.1631/FITEE.2100580

摘要：第五代无线通信系统(5G)的发展使元启发算法与电磁设备的设计过程结合得更为紧密。本文提出一种自适应灰狼优化器（SAGWO），并将其与一种基于单元节点的5G频率选择面（FSS）优化模型相结合。在基准函数测试中，SAGWO优于其他5种优化算法：原始灰狼优化器（GWO）、遗传算法（GA）、粒子群优化器（PSO）、改进灰狼优化算法（IGWO）和基于选择性对抗的灰狼优化算法（SOGWO）。因为SAGWO具有良好全局寻优能力，所以SAGWO适用于解决具有较大设计空间的5G FSS优化问题。将SAGWO与新的FSS优化模型相结合，能自动生成在中心工作频率处具有电磁屏蔽能力的FSS结构。

关键词：灰狼优化算法；第五代无线通信系统（5G）；频率选择面；形状优化

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Responses of bacterial strains isolated from drinking water environments to N-acyl-L-homoserine lactones and their analogs during biofilm formation

Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU

《环境科学与工程前沿（英文）》 2014年第8卷第2期页码 205-214 doi: 10.1007/s11783-013-0492-5

摘要： Often as a result of biofilm formation, drinking water distribution systems (DWDS) are regularly faced with the problem of microbial contamination. Quorum sensing (QS) systems play a marked role in the regulation of microbial biofilm formation; thus, inhibition of QS systems may provide a promising approach to biofilm formation control in DWDS. In the present study, 22 bacterial strains were isolated from drinking water-related environments. The following properties of the strains were investigated: bacterial biofilm formation capacity, QS signal molecule N-acyl-L-homoserine lactones (AHLs) production ability, and responses to AHLs and AHL analogs, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and 2(5H)-furanone. Four AHLs were added to developed biofilms at dosages ranging from 0.1?nmol·L to 100 nmol·L . As a result, the biofilm growth of more than 1/4 of the isolates, which included AHL producers and non-producers, were significantly promoted. Further, the biofilm biomasses were closely associated with respective AHLs concentrations. These results provided evidence to support the idea that AHLs play a definitive role in biofilm formation in many of the studied bacteria. Meanwhile, two AHLs analogs demonstrated unexpectedly minimal negative effects on biofilm formation. This suggested that, in order to find an applicable QS inhibition approach for biofilm control in DWDS, the testing and analysis of more analogs is needed.

关键词： drinking water distribution systems (DWDS) biofilm quorum sensing (QS) N-acyl-L-homoserine lactones (AHLs) (dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) 2(5H)-furanone

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UI图层合并器：基于计算机视觉与边界先验的UI图层合并方法 Research Article

陈云农1,5,甄焱鲲4,施楚宁2,李佳智2,陈柳青2,3,5,李泽健1,3,5,孙凌云2,3,5,周婷婷4,常艳芳4

《信息与电子工程前沿（英文）》 2023年第24卷第3期页码 373-387 doi: 10.1631/FITEE.2200099

摘要：随着互联网行业图形用户界面（GUI）开发工作量的快速增长，国内外学者试图从GUI图片生成可维护的前端代码。该任务更适合从包含有用户界面元数据的UI设计稿来实现代码生成。然而，碎片图层不可避免地会出现在UI设计稿中，这大大降低了生成代码的质量。目前尚未有自动化GUI技术来检测并合并碎片图层以提高生成代码的可维护性。本文提出UI图层合并器（UILM），一种基于计算机视觉的方法，可以自动检测并合并碎片图层为完整的UI组件。本文提出的UILM包含合并区域检测器和碎片图层合并算法。合并区域检测器结合边界先验知识来准确地检测出UI组件的边界。基于此，碎片图层合并算法可以搜索出边界内的相关碎片层并将其合并为整体。此外，我们提出一种动态数据增强算法来提高合并区域检测器的性能。我们还构建了用于训练合并区域检测器和测试UILM的大规模UI数据集。实验结果表明，本文提出的方法在合并区域检测方面优于最佳基线，并达到了有效的图层合并准确率。最后，对真实应用程序的用户研究也证实了本文方法的有效性。

关键词：用户界面（UI）生成代码；UI设计规范；UI碎片图层合并；目标检测

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基于半导体纳米晶体的神经突触器件 Review

步明轩1,2,王越1,2,尹蕾1,2,童周禹1,2,张懿强3,杨德仁1,2,4,5,皮孝东1,2,4,5

《信息与电子工程前沿（英文）》 2022年第23卷第11期页码 1579-1601 doi: 10.1631/FITEE.2100551

摘要：

近年来，人们对信息处理的需求日益增长，脑启发式神经形态器件得到了广泛的关注。突触器件作为一类重要的神经形态器件，在短短几年内迅速升温。在用于制备突触器件的各种材料中，半导体纳米晶体（NCs）因其优异的电学和光学性能而成为首选材料之一。本综述论文首先介绍了基于半导体纳米晶体的突触器件的研究背景及半导体纳米晶体的基本性质。然后，根据器件有源层所用纳米晶体种类的不同，分类介绍了基于纳米晶体的突触器件的最新研究进展。最后，讨论了基于半导体纳米晶体的突触器件目前仍面临的问题和挑战。

关键词：半导体纳米晶体；突触器件；神经形态计算

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Mutation analysis of KCNQ1, KCNH2, SCN5A, KCNE1 and KCNE2 genes in Chinese patients with long QT syndrome

DU Rong, TIAN Li, YUAN Guohui, LI Jin, REN Faxin, GUI Le, LI Wei, ZHANG Shouyan, KANG Cailian, YANG Junguo

《医学前沿（英文）》 2007年第1卷第3期页码 312-315 doi: 10.1007/s11684-007-0060-0

摘要： Long QT syndrome (LQTS) is the prototype of the cardiac ion channelopathies, which cause syncope and sudden death. Inherited LQTS is represented by the autosomal dominant Romano-ward syndrome (RWS), which is not accompanied by congenital deafness, and the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS), which is accompanied by congenital deafness. The LQTS-causing mutations have been reported in patients and families from Europe, North America and Japan. Few genetic studies have been carried out in families with JLNS from China. This study investigates the molecular pathology in four families with LQTS (including a family with JLNS) in the Chinese population. Polymerase chain reaction and DNA sequencing were used to screen for , , , and mutation. A missense mutation G314S in an RWS family was identified, and a single nucleotide polymorphism (SNP) G643S was indentified in the of the JLNS family. In this JLNS family, another heterozygous novel mutation in exon 2a was found in of the patients. Our data provide useful information for the identification of polymorphisms and mutations related to LQTS and the Brugada Syndrome (BS) in Chinese populations.

关键词： recessive Jervell LQTS-causing population autosomal dominant syndrome

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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

《医学前沿（英文）》 2019年第13卷第3期页码 289-297 doi: 10.1007/s11684-018-0667-3

摘要： Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamics. By facilitating cell reprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumour metastasis. Here we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

关键词： cancer-testis TH2B TH2A H1T H1.0 H1F0 linker histones

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The effect of doping and steam treatment on the catalytic activities of nano-scale H-ZSM-5 in the methanol

Baodong Song, Yongqiang Li, Gang Cao, Zhenhai Sun, Xu Han

《化学科学与工程前沿（英文）》 2017年第11卷第4期页码 564-574 doi: 10.1007/s11705-017-1654-y

摘要： In the transformation of methanol to gasoline (MTG), the selectivity to gasoline and the aromatic content in the produced gasoline are important factors. The catalytic activities of steam-treated and non-steam-treated nano-scale H-ZSM-5 (NHZ5) catalysts impregnated with Ag(I), Zn(II) or P(V) have been investigated in a continuous flow fixed bed reactor. The NH -TPD results showed that after impregnation, the Ag/NHZ5, Zn/NHZ5 and P/NHZ5 catalysts contained comparatively more strong, medium-strong and weak acid sites, respectively. Treatment with steam decreased the number of acid sites in all the catalysts, but the pore volumes in the catalysts were larger which improved carbon deposition resistance resulting in prolonged lifetimes. After 6 h of MTG reaction, the selectivity to gasoline for the steam-treated catalysts, , and were 70.5, 68.4 and 68.7 wt-%, respectively, whereas their respective aromatic contents in the produced gasoline were 61.9, 55.4 and 39.0 wt-%. Thus is the most promising catalyst for MTG applications which can meet the China IV gasoline standard that the amount of aromatics in gasoline should be less than 48 wt-%.

关键词： MTG nano-scale H-ZSM-5 steam treatment gasoline selectivity to gasoline

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一种用于用户端设备且工作在2G/3G/4G/IMT/5G频段的小型化超宽带交叉振子天线 Correspondences

郭景丽1,崔伦1,刘英1,孙保华1,李肖锋2

《信息与电子工程前沿（英文）》 2022年第23卷第2期页码 339-345 doi: 10.1631/FITEE.2000456

摘要：设计了一种用于用户端设备（CPE）且工作在2G/3G/4G/IMT/5G频段的小型化超宽带交叉振子天线。此外，通过在交叉振子下方增加开缝的寄生贴片，天线整体的带宽能够扩展到5G sub-6 GHz频段。此外，对天线结构进行了加工和测试。

关键词： 5G；交叉振子；双极化天线；终端天线；超宽带

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纹理分支网络：基于超声影像的慢性肾脏病筛查模型 Research Articles

郝鹏翼1,5,徐震宇1,田树元2,吴福理1,5,陈为3,5,吴健4,5,罗笑南6

《信息与电子工程前沿（英文）》 2020年第21卷第8期页码 1119-1266 doi: 10.1631/FITEE.1900210

摘要：慢性肾脏病是一种在世界范围内广泛存在的肾脏疾病。该疾病一旦发展到晚期，伴随而来的是严重并发症与较高死亡风险。因此，早期筛查对于慢性肾脏病诊治至关重要。超声作为一种无创方法，能动态观察肾脏形态和病理特征，常用于肾脏检查。本文提出一种新的卷积神经网络模型，称为纹理分支网络，基于超声影像作慢性肾脏病筛查。该模型通过在经典卷积神经网络中引入纹理分支来提取和优化纹理特征，可自动生成输入图像的纹理特征和深度特征，并使用融合信息进行分类。此外，通过迁移学习训练网络的主干部分，并在具有226张超声影像的数据集上开展实验。实验结果表明，该模型准确率和敏感度分别达到96.01%和99.44%，在慢性肾脏病筛查上具有一定有效性。

关键词：慢性肾脏病；超声；纹理分支网络；迁移学习

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一种用于5G金属边框智能手机的高隔离度耦合馈电模块 Correspondence

任爱娣1,余成苇1,杨利霞1,崔巍2,黄志祥1,刘英3

《信息与电子工程前沿（英文）》 2023年第24卷第11期页码 1657-1664 doi: 10.1631/FITEE.2300203

摘要：提出一款应用于第五代金属边框智能手机的高隔离度两天线模块。基于一个蚀刻在地板上的T形缝隙，通过合理地设计一个耦合馈电环天线和一个耦合馈电缝隙天线，实现了一款紧凑的两天线模块。尽管耦合馈电环天线和耦合馈电缝隙天线共口径，两者之间的隔离度高于30 dB。随后，通过集成4个两天线模块，实现了一款8×8多入多出系统。该系统实测互耦和包络相关系数分别小于−18.5 dB和0.02。

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